Kit for the preparation of technetium tc99m sulfur colloid. If signs of cyanide poisoning reappear, repeat treatment using onehalf the original dose of both sodium nitrite and sodium thiosulfate. The solid is an efflorescent loses water readily crystalline substance that dissolves well in water sodium thiosulfate is used in gold mining, water treatment, analytical chemistry, the development. Sodium nitroprusside should be used only when available equipment and personnel allow blood pressure to be continuously monitored.
The drug is intended for single use only and contains no bacteriostatic agent. Selenium injection is a sterile, nonpyrogenic solution for use as an additive to solutions for total parenteral nutrition tpn. Sodium thiosulfate serves as a sulfur source and, in combination with ferric citrate, detects hydrogen sulfide production. Add 5 ml of sodium thiosulfate solution and incubate rotating for 1 min.
Sodium thiosulfate injection fda prescribing information. Sodium thiosulfate an overview sciencedirect topics. Inject 310 ml subcutaneously into extravasation site. Phosphate injection availability frequently asked questions q.
When the diagnosis of cyanide poisoning is uncertain, the potential risks associated with sodium thiosulfate injection should be carefully weighed against the potential. Patient information leaflet sodium thiosulfate 250 mgml. Sodium thiosulfate 50 ml of sodium thiosulfate immediately following administration of sodium nitrite. Stability of sodium nitroprusside and sodium thiosulfate 1. Please see product packaging and package insert for complete expiration date and storage requirements. In one study, sodium thiosulfate appeared to potentiate the hypotensive effects of sodium nitroprusside. Sucrose is included as a fermentable carbohydrate for the metabolism of vibrios. If patient is conscious, then sodium thiosulfate may be administered as an antidote by itself. Thymol blue and bromthymol blue are included as indicators of ph changes.
Medscape indicationspecific dosing for sodium thiosulfate, frequencybased. Except when used briefly or at low 2 mcgkgmin infusion rates, sodium nitroprusside gives rise to important quantities of cyanide ion, which can reach toxic, potentially lethal levels see warnings. Various lot numbers and seven 250 ml 5% dextrose and water d5w bags baxter healthcare corp. Glycophos is sodium glycerophosphate, which is an organic phosphate. Each monograph contains stability data, administration guidelines, and methods of preparation. Cocoinfusions of sodium thiosulfate have been administered at rates of 510 times that of sodium nitroprusside. Use in lifethreatening emergencies when no safer drug available. At 6 weeks, most skin lesions had completely resolved. Other information sodium thiosulfate injection, usp is indicated for the treatment of cyanide poisoning. Promethazine hydrochloride injection, usp 50 mgml x 25. One 50 ml glass vial of sodium thiosulfate injection 250 mgml containing 12. This dosing is based on limited and varied information.
Nithiodote sodium nitrite injection usp and sodium thiosulfate injection usp for intravenous infusion. At 8 weeks, sodium thiosulfate therapy was discontinued. See antidote package information insert sodium thiosulfate 12. Mix 4 ml of sodium thiosulfate 10% with 6 ml sterile water for injection to prepare a 0. Intravenous iv preparation and infusion guidelines globalrph. Sodium thiosulfate injection is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be serious or lifethreatening. Package insert protamine sulfate injection, usppiengv1.
Intravenous admixtures preparation and infusion guidelines. Hydroxocobalamin is also chemically incompatible with sodium thiosulfate and sodium nitrite and has been reported to be incompatible with ascorbic acid. Oral glycine and sodium thiosulfate for lethal cyanide ingestion. Sodium thiosulfate is indicated for sequential use with sodium nitrite for the treatment of acute cyanide poisoning that is judged to be lifethreatening. Dbl sodium thiosulfate injection 25% wv solution for injection. Sodium thiosulfate solution for injection summary of.
The inclusion of cobalt is based on its marked antagonistic effect against cyanide, which may be enhanced by combination. Follow your doctors orders or the directions on the label. Sodium thiosulfate we6660000 8b inventory sodium thiosulfate health 2, fire 0, reactivity 0 not controlled section 16. Do not use if solution has developed color or contains a precipitate. Refer to the glycophos package insert for full prescribing information. Approval type 5 new formulation or new manufacturer. Sodium phosphates and potassium phosphates contain 3 mmol of phosphate per ml. A 23 gauge 1inch catheter was then inserted in the marginal. General instructions for immunohistochemical staining. If reagents are stored under conditions other than those specified in the package insert, they.
Sodium thiosulfate intravenous route proper use mayo. Sodium thiosulfate is a component of the cyanide antidote package. Sodium thiosulfate solution for injection patient information leaflet pil by hope pharmaceuticals ltd. The colilert test uses proprietary defined substrate technology dst to simultaneously detect total coliforms and e. The dose of this medicine will be different for different patients. Solution for injection read all of this leaflet carefully this leaflet contains. Treatment, whichever product is used, may have to be repeated because of further liberation of hcn. The active ingredient is represented by the following structural formula. The alkaline ph of the medium enhances the recovery of v. After nonresponse to conventional therapy, treatment with intravenous sodium thiosulfate 3 times weekly was begun, and she had rapid and dramatic relief of signs and symptoms and improvement of technetium scans. Bleph 10 sulfacetamide sodium ophthalmic solution, usp. Typically it is available as the white or colorless pentahydrate, na 2 s 2 o 3 5h 2 o.
Sodium thiosulfate injection sodium thiosulfate is an antidote to cyanide poisoning and an antineoplastic adjunct. Sodium thiosulfate sodium thiosulphate is an inorganic compound with the formula na 2 s 2 o 3. Pain decreased and skin lesions resolved within 2 weeks. The molecular formula is na 2 s 2 o 3,5h 2 o and molecular weight is 248. Injection and sodium thiosulfate solution for injection. Nithiodote is a kit that contains two separate medications. Successful treatment of calciphylaxis with intravenous. Glycophos contains 20 mls in each plastic vial for a total.
All investigators ascribed the beneficial effect of sodium thiosulfate to the extremely high soluability of ca thiosulfate salts resulting in inhibition of precipitation of ca salts and dissolution of ca deposits with resultant mobilization of the tumorlike masses. Sodium nitrite 10 ml of sodium nitrite at the rate of. Prior to immunostaining, clear tissue sections of mercury deposits using an iodineethanol sodium thiosulfate solution. When a solution of sterile and nonpyrogenic sodium pertechnetate tc. The solution for injection is a clear and colourless sterile solution. These highlights do not include all the information needed to use the sodium thiosulfate injection safely and.
Intravenous dose of sodium nitrite and sodium thiosulfate adults. Cinacalcet was discontinued, and sodium thiosulfate was started at a dosage of 25 g 3 times per week after dialysis. Two nutrientindicators, onpg and mug, are the major sources of carbon in colilert and can be metabolized by the coliform enzyme. Care must be taken to avoid the indiscriminate use of prolonged or high doses of sodium nitroprusside with sodium thiosulfate as. For nonprescription products, read the label or package ingredients carefully. Chemically, sodium thiosulfate is thiosulfuric acid disodium salt, pentahydrate. Sodium thiosulfate 1 mlkg of body weight 250 mgkg or approximately 3040 mlm 2 of bsa not to exceed 50 ml total dose immediately following administration of sodium nitrite. Sodium hydroxide or hydrochloric acid may be present to adjust ph to 5. Refer to luitpold american regents prescribing information for. Reconstitution for parenteral administration the normal adult dose of 2 million units should be dissolved in 1050 ml of 0. Phosphate injection availability frequently asked questions. Pediatric although there is no specific information comparing use of sodium thiosulfate in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. Prolonged treatment was well tolerated without serious side effects and accompanied by continued clinical improvement. One 10 ml glass vial of sodium nitrite injection 30 mgml containing 300 mg of sodium nitrite.
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